The aim of this study was to evaluate whether the exposure to 50 Hz extremely low frequency electric fields can cause oxidative stress in guinea pig brain.
112, approximately 14-week-old, white male guiena pigs were used. Eight hours after exposure period animals were anesthetized and sacrificed by decapitation.
Exposure | Parameters |
---|---|
Exposure 1:
50 Hz
Exposure duration:
continuous for 8 h/day on 3 days
|
|
fields were applied a) in vertical direction b) in horizontal direction
Frequency | 50 Hz |
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Type | |
Exposure duration | continuous for 8 h/day on 3 days |
Exposure source |
|
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Setup | 80 cm x 80 cm x 18 cm wooden frame with copper plates on the top and bottom (vertical field) or on the right and left side (horizontal field); guinea pigs in a plastic cage inside the frame |
Sham exposure | A sham exposure was conducted. |
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
electric field strength | 2 kV/m | minimum | measured and calculated | - | - |
electric field strength | 2.5 kV/m | - | measured and calculated | - | - |
electric field strength | 3 kV/m | - | measured and calculated | - | - |
electric field strength | 3.5 kV/m | - | measured and calculated | - | - |
electric field strength | 4 kV/m | - | measured and calculated | - | - |
electric field strength | 4.5 kV/m | - | measured and calculated | - | - |
electric field strength | 5 kV/m | maximum | measured and calculated | - | - |
No significant differences among all of the exposure groups and sham exposure groups were found in lipid peroxidation levels and enzyme activities at all electric field strengths and in both field directions.
The authors suggest that further research studies are required to determine the effects of electric fields stronger than 5 kV/m as slight tendencies of changes with higher electric field strenghts could be observed.
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