Study type: Medical/biological study (experimental study)

Increased mouse survival, tumor growth inhibition and decreased immunoreactive p53 after exposure to magnetic fields med./bio.

By: Tofani S, Cintorino M, Barone D, Berardelli M, de Santi MM, Ferrara A, Orlassino R, Ossola P, Rolfo K, Ronchetto F, Tripodi SA, Tosi P
Published in: Bioelectromagnetics 2002; 23 (3): 230-238
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Aim of study (acc. to author)

To investigate the effects of a modulated magnetic field on survival time and tumor growth in mice.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: 70 min/day, 5 days/week, until death or for 4 consecutive weeks

Exposure 1

Main characteristics
Frequency
Type
Waveform
Exposure duration 70 min/day, 5 days/week, until death or for 4 consecutive weeks
Additional info static magnetic field with a superposition of 50 Hz magnetic field
Modulation
Modulation type cf. additional info
Additional info

DC + 50 Hz
Exposure setup
Exposure source
Setup pair of coils with the axis in the same plane; plexiglas box 14.7 x 3.6 x 3.6 cm placed between the 2 coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 5.5 mT average over time measured - -
magnetic flux density 1 mT effective value measured - 50 Hz magnetic field component
magnetic flux density 2.5 mT effective value measured - 50 Hz magnetic field component
magnetic flux density 3 mT effective value measured - static component
magnetic flux density 4 mT effective value measured - static component

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Mice subcutaneously inoculated with a human colon adenocarcinoma (WiDr) were used in this study. Two different experiments were conducted. In the first experiment the suvival time of mice should be investigated Animals were MF-exposed daily for 70 min, 5 days a week until death. In a second experiment the tumor growth sould be examined. At this animals were MF-exposed for four consecutive weeks.
The survival time of MF-exposed mice were statistically significant increased (31%) compared with sham-exposed controls.
The tumor growth of the MF-exposed mice were statistically significant inhibeted (40%) compared with sham-exposed controls. Together with a reduced p53 expression a significant increase in apoptosis was found in tumors of MF-exposed aminals. These findings suggest a anti-cancer capacity of magnetic fields.

Study character:

Study funded by

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