Immunology. Abbr. of cluster of differentiation. Cell surface markers expressed by cells of the immune system (lymphocytes) and used to distinguish cell lineages and developmental stages which can not be diffentiated by morphology. CD antigens can be identified by specific monoclonal antibodies and are numbered CD1, CD2, CD3, etc.
The symbols + and - are used to indicate if a certain fraction of cells possesses or lacks a CD molecule; for example, a CD4+CD25- cell expresses CD4, but not CD25.
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