The effects of exposure of male rats to a 3 Hz or 60 Hz electro-magnetic field on memory, anxiety and neuronal activity in the brain should be investigated.
A total of 90 rats were divided into 3 groups: 1) exposure to the 3 Hz magnetic field (n=30), 2) exposure to the 60 Hz magnetic field (n=30) and 3) sham exposure (n=30). For further 23 rats used in neuronal activity investigations, the subdivision is not clear.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
3 Hz
Exposure duration:
2 hours/day during 2 exposure trails of 4 days each, separated by an interval of 2 days
|
|
|
Exposure 2:
3 Hz
Exposure duration:
continuous for 2 hours
|
|
|
Exposure 3:
60 Hz
Exposure duration:
2 hours/day during 2 exposure trails of 4 days each, separated by an interval of 2 days
|
|
|
Exposure 4:
60 Hz
Exposure duration:
continuous for 2 hours
|
|
| Exposure source | |
|---|---|
| Chamber | plastic cage without any metallic cover in shielded room |
| Setup | the antenna was placed at the center of an aluminum mesh shielded room with dimensions of 1.5 m Œ 2 m Œ 2 m; the center of the animal cage was placed at a distance of 40 cm from effective radiative surface of the antenna on a wooden stage with a distance of 50 cm from the ground; room temperature was kept at 23 ± 2.0°C |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 4 mT | - | calibration | - | - |
| Frequency | 3 Hz |
|---|---|
| Type | |
| Exposure duration | continuous for 2 hours |
| Exposure source | |
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 4 mT | - | calibration | - | - |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 4 mT | - | calibration | - | - |
| Frequency | 60 Hz |
|---|---|
| Type | |
| Exposure duration | continuous for 2 hours |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 4 mT | - | calibration | - | - |
Directly after exposure, the locomotor activity of rats in both exposure groups (groups 1 with 3 Hz and group 2 with 50 Hz) was significantly decreased compared to the sham exposure group. Moreover, a significant reduction in the action potential rate of brain neurons was found in both exposure groups compared to the sham exposure group.
Proteome analysis in the brain revealed changes in protein expression, but no specifications on significance and affected genes were given.
All other parameters did not show any significant differences between the groups.
The authors conclude that exposure of rats to a 3 Hz or 60 Hz electro-magnetic field might affect motor activity and neuron action potential rate in the brain.
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