Medical/biological study (experimental study)

Structural and Ultrastructural Study of Rat Liver Influenced by Electromagnetic Radiation med./bio.

By: Holovska K, Almasiova V, Cigankova V, Benova K, Racekova E, Martoncikova M

Published in: J Toxicol Environ Health A 2015; 78 (6): 353-356

The effects of exposure of rats to a pulsed 2.45 GHz electromagnetic field on the structure and ultrastructure of the liver should be investigated.

40 rats were divided into 2 groups (n=20 each): 1) control group and 2) exposure to the electromagnetic field. All animals were anesthetized and examined 3 hours after the last exposure session.

Exposure	Parameters
Exposure 1: 2.45 GHz Exposure duration: continuous for 3 h/day for 3 weeks	power density: 2.8 mW/cm² mean

Frequency	2.45 GHz
Type	electromagnetic field
Waveform	pulsed
Exposure duration	continuous for 3 h/day for 3 weeks

Exposure source	not specified
Chamber	purpose-designed chamber

Measurand	Value	Type	Method	Mass	Remarks
power density	2.8 mW/cm²	mean	-	-	-

Exposed system:

Investigated system:

Time of investigation:

Microscopy showed a slightly increased blood flow, dilatation of liver sinusoids and small inflammatory foci in the centers of liver lobules in the exposure group compared to the control group. The morphology of hepatocytes was not altered and all observed changes were classified as moderate.
Electron microscopy of hepatocytes revealed more vesicles, lipid droplets and growth of the smooth endoplasmic reticulum in cells of the exposure group compared to the control group. Occasionally, necrotic cells were found in the exposure group but not in the control group.
The authors conclude that exposure of rats to a pulsed 2.45 GHz electromagnetic field could have adverse effects on the liver.

Study character:

Djordjevic B et al. (2015): The effect of melatonin on the liver of rats exposed to microwave radiation
Kumari K et al. (2012): Radiofrequency electromagnetic field exposure effects on antioxidant enzymes and liver function tests
Jin YB et al. (2011): One-year, simultaneous combined exposure of CDMA and WCDMA radiofrequency electromagnetic fields to rats
Esmekaya MA et al. (2011): 900 MHz pulse-modulated radiofrequency radiation induces oxidative stress on heart, lung, testis and liver tissues
Tarantino P et al. (2005): Post-continuous whole body exposure of rabbits to 650 MHz electromagnetic fields: effects on liver, spleen, and brain
Gokcimen A et al. (2002): The effect of melatonin on morphological changes in liver induced by magnetic field exposure in rats
Dasdag S et al. (1999): Whole-body microwave exposure emitted by cellular phones and testicular function of rats
Dwivedi RS et al. (1989): Low intensity microwave radiation effects on the ultrastructure of Chang liver cells

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