To test the feasibility of studying the electrical activity of neuronal networks under radio frequency-exposure at 1800 MHz in vitro.
In many studies, indications of an effect of radiofrequency electromagnetic fields on the human EEG have been found (for example Schmid et al., 2012; Croft et al., 2010). To clarify the mechanisms underlying these potential effects on the brain, the research group has developed an experimental setup for the simultaneous exposure of neuronal networks and monitoring the electrical activity.
Recordings were made 3 minutes before, three minutes during and three minutes after the exposure period with 16 independent cultures.
| Frequency | 1,800 MHz |
|---|---|
| Type | |
| Exposure duration | continuous for 3 minutes |
| Exposure source | |
|---|---|
| Chamber | 6 mm-high glass cylinder, sealed with biocompatible silicone was used as a culture chamber and put on a microelectrode array |
| Setup | microelectrode array (60 platinum electrodes, 200 µm spaced with 40 µm diameter tips) with culture chamber was placed inside the TEM cell in an incubator (37°C, 5 % CO2) |
| Sham exposure | A sham exposure was conducted. |
No differences in the electrical activity were observed before and after the exposure or sham exposure. However, during exposure, the firing rate and the bursting rate were significantly decreased (around 30 %) in comparison to sham exposure.
The authors demonstrated the feasibility of studying the electrical activity of neuronal networks under radio frequency-exposure at 1800 MHz in vitro.
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