Epidemiological study (observational study)

Case-control study of paternal occupation and childhood leukaemia in Great Britain, 1962-2006 epidem.

By: Keegan TJ, Bunch KJ, Vincent TJ, King JC, O'Neill KA, Kendall GM, MacCarthy A, Fear NT, Murphy MF

Published in: Br J Cancer 2012; 107 (9): 1652-1659

Aim of study (acc. to author)

A case-control study was conducted in the Great Britain to investigate the possible association between paternal occupation and the risk for childhood leukemia.

Endpoint/type of risk estimation

childhood leukemia: total childhood leukemia, lymphoid leukemia, acute myeloid leukemia, other types of leukemia

Type of risk estimation:

incidence

(odds ratio (OR))

Exposure

- 50/60 Hz
- magnetic field
- also other exposures without EMF
- occupational

Assessment

list: paternal occupation stated on birth certificate was categorized according to the 1980 Office of Population Censuses and Surveys Classification of Occupations

Population

Group:
- children
- children in utero
Age: 0–14 years
Observation period: 1962 - 2006
Study location: Great Britain

Case group

Characteristics: childhood leukemia
Data source: National Registry of Childhood Tumours, Office for National Statistics, General Registry for Scotland
Exclusion criteria: children born overseas, adopted children, no birth registration found

Control group

Matching:
- sex
- age
- birth registration district
- case:control = 1:1

Study size

	Cases	Controls
Eligible	17,793	16,764
Evaluable	16,764	16,764

Statistical analysis method:

conditional logistic regression

(adjustment:

social class

)

Results (acc. to author)

No statistically significant increased risks for total childhood leukemia, lymphatic leukemia, and acute myeloid leukemia were observed in association with paternal exposure to electromagnetic fields. However, the risk of other types of leukemia was significantly increased by paternal exposure to electromagnetic fields (adjusted OR 1.60; CI 1.11-2.33 based on 119 case-control pairs).
The authors concluded that the results show some support for a positive association between childhood leukemia risk and paternal occupation involving social contact. Additionally, the study provided additional evidence for higher occupational social class being a risk factor for childhood leukemia.

Study funded by

CHILDREN with CANCER UK
Department of Health, UK
Scottish Executive/Scottish Ministers, UK

Talibov M et al. (2019): Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)
Su L et al. (2018): Association between parental occupational exposure to extremely low frequency magnetic fields and childhood nervous system tumors risk: A meta-analysis
Su L et al. (2016): Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk
Zhao L et al. (2014): Magnetic fields exposure and childhood leukemia risk: a meta-analysis based on 11,699 cases and 13,194 controls
Sermage-Faure C et al. (2013): Childhood leukaemia close to high-voltage power lines--the Geocap study, 2002-2007
Schüz J et al. (2012): Extremely low-frequency magnetic fields and survival from childhood acute lymphoblastic leukemia: an international follow-up study
Reid A et al. (2011): Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to extremely low frequency electromagnetic fields
Hug K et al. (2010): Parental occupational exposure to extremely low frequency magnetic fields and childhood cancer: a German case-control study
Li P et al. (2009): Maternal occupational exposure to extremely low frequency magnetic fields and the risk of brain cancer in the offspring
Kheifets L et al. (2009): Future needs of occupational epidemiology of extremely low frequency electric and magnetic fields: review and recommendations
Pearce MS et al. (2007): Paternal occupational exposure to electro-magnetic fields as a risk factor for cancer in children and young adults: a case-control study from the North of England
Infante-Rivard C et al. (2003): Maternal occupational exposure to extremely low frequency magnetic fields during pregnancy and childhood leukemia
Cordier S et al. (2001): Parental occupations and childhood brain tumors: results of an international case-control study
De Roos AJ et al. (2001): Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring
Feychting M et al. (2000): Parental occupational exposure to magnetic fields and childhood cancer (Sweden)
Greenland S et al. (2000): A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Childhood Leukemia-EMF Study Group
Ahlbom A et al. (2000): A pooled analysis of magnetic fields and childhood leukaemia
Smulevich VB et al. (1999): Parental occupation and other factors and cancer risk in children: II. Occupational factors
Sorahan T et al. (1999): Maternal occupational exposure to electromagnetic fields before, during, and after pregnancy in relation to risks of childhood cancers: findings from the Oxford Survey of Childhood Cancers, 1953-1981 deaths
Michaelis J et al. (1998): Combined risk estimates for two German population-based case-control studies on residential magnetic fields and childhood acute leukemia
Michaelis J et al. (1997): Childhood leukemia and electromagnetic fields: results of a population-based case-control study in Germany