To study electromagnetic field induced alterations of ovary follicles at the cellular level to find out whether electromagnetic field exposure can increase the incidence of apoptosis in follicular cells and oocytes.
30 female rats were divided into a control group and an exposure group.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
4 h/day for 4 months
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | 4 h/day for 4 months |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 3 mT | - | - | - | - |
Compared to the control group, ultrastructural alterations in oocytes were present in the electromagnetic field exposed rats: Zona pellucida appeared condensed and narrower. Granulosa cells were condensed and lost contact with oocytes or neighbor-cells. The number of microvilli was decreased and in their cytoplasm several lipid droplets and organelles were dispersed. The nuclei of the oocytes appeared irregular in shape and the nucleoli were not as developed as in controls. Granulosa cells near the basal lamina showed features of apoptosis: nuclear condensation, changes in nuclear morphology, appearance of autophagic vacuoles and apoptotic bodies, separation of cells from neighboring cells.
Present results suggest that electromagnetic field exposure may interfere with normal processes of folliculogenesis.
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