To evaluate at which magnetic flux density the exposure to static magnetic field suppresses and delays blood pressure elevation in spontaneously hypertensive rats.
The study was an attempt to partially replicate previous findings (publication 10200).
| Exposure | Parameters |
|---|---|
|
Exposure 1:
Exposure duration:
continuous for 12 weeks
|
|
|
Exposure 2:
Exposure duration:
continuous for 12 weeks
|
|
Rats divided into 3 groups (n=20/group) were treated under the following conditions: sham exposure with ip (interperitoneal) saline injection, exposure to 2 mT MF (magnetic field) with ip saline injection and exposure to 5 mT MF with ip saline injection
| Frequency | |
|---|---|
| Type | |
| Exposure duration | continuous for 12 weeks |
| Additional info | Static magnetic field exposure |
| Exposure source |
|
|---|---|
| Chamber | Transparent acrylic cage (40 cm long x 24 cm wide x 20 cm high) enclosed in paperboards avoiding the rats to see the magnetic plates. |
| Setup | The rats head position throughout the experiment was in the range of ± 19 cm,± 8 cm, ±12 cm x,y,z respectively. |
| Additional info | The exposure device (41 cm long x 29.6 cm wide x 16 cm high) composed of a pair of metal plates (41 cm long x 16 cm high x 0.6 cm or 1 cm diameter). The plates were attached to the outer walls of the cage. The mimimum distance between the inside of the magnetic plates was 26 cm and the magnetic field was attractive. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 550 µT | mean | measured | - | at the center of the cage; Bmax between 0.3 to 1 mT hence referred to as 1 mT field |
| Frequency | |
|---|---|
| Type | |
| Exposure duration | continuous for 12 weeks |
| Additional info | Static magnetic field exposure |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2.8 mT | mean | measured | - | at the center of the cage; Bmax between 1.5 to 5 mT hence referred to as 5 mT field |
The data showed that the exposure to static magnetic field at 5 mT, but not 1 mT, significantly suppressed and retarded the early stage development of hypertension for several weeks in spontaneously hypertensive rats compared with the age matched, sham exposed control animals. Exposure to 5 mT resulted in reduced plasma concentrations of nitric oxide metabolites together with lower levels of the hormones angiotensin II and aldosterone.
These results suggested that exposure to static magnetic field may suppress and delay the elevation of blood pressure via the nitric oxide pathways and hormonal regulatory systems.
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