Study type: Medical/biological study (experimental study)

Effects of static magnetic fields on plasma levels of angiotensin II and aldosterone associated with arterial blood pressure in genetically hypertensive rats med./bio.

By: Okano H, Ohkubo C
Published in: Bioelectromagnetics 2003; 24 (6): 403-412
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Aim of study (acc. to author)

To investigate the effects of static magnetic fields on development of hypertension in rat.

Background/further details

Spontaneously hypertensive rats (SHR) rats were used which showed the following characteristics: hypertension, insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypercholesterolemia.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: 12 weeks
Exposure 2:
Exposure duration: 6 weeks or 12 weeks

Exposure 1

Main characteristics
Frequency
Exposure duration 12 weeks
Additional info Static MF.
Exposure setup
Exposure source
  • Permanent magnetic plates (alloy of strontium ferrite SrFe12O19)
Chamber Acrylic cage/ 38 cm long x 16 cm high x 24 cm wide
Setup Magnetic plates (41 cm long x 16 cm high x 1 cm or 0.6 cm in diameter) placed at c.a 1 cm parallel to the cage.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 3 mT minimum measured - 10 mT max value; mean value of 5.5 mT at the center of the cage.

Exposure 2

Main characteristics
Frequency
Exposure duration 6 weeks or 12 weeks
Additional info Static MF.
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 8 mT minimum measured - 25 mT max value; mean value of 14 mT at the center of the cage.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The development of hypertension was suppressed and retarded by magnetic field exposure. No significant differences of blood pressure were seen between 10 mT and 25 mT exposure. No effects were observed on body weight and heart rate compared with control. Afer 5 weeks of exposure a significantly reduced concentration of aldosterone and angiotensin II were observed. This effect disappeared after 12 weeks of exposure. No other effects on blood pressure regulating hormones or enzymes were detected.

Study character:

Study funded by

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