Electrophysiology. Temporary or permanent damage of the cell membrane by very short intensive pulses of electric current. Electroporation is a possible mechanism of an electrical injury leading to tissue damage.
Electroporation can be applied to introduce genetic material into cells. Strong electric fields (up to 1500 V/cm) are applied to the cells for a short time (approx. 1 msec) thus leading to reversible pores in the cell membranes. While the cells are porous, fluids and substances (e.g., DNA) can enter into the cytoplasm.
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