Study type: Medical/biological study (experimental study)

Effects of long-term exposure to an extremely low frequency magnetic field (15 µT) on selected blood coagulation variables in OF1 mice med./bio.

By: Vallejo D, Hidalgo MA, Hernández JM
Published in: Electromagn Biol Med 2019; 38 (4): 279-286
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Aim of study (acc. to author)

The effects of prenatal and postnatal exposure of mice to a 50 Hz magnetic field on blood coagulation should be investigated.

Background/further details

Mice of both sexes were maintained and exposed separately to the magnetic field for 14 weeks. Then they were allowed to mate and gestation, birth, lactation, weaning and the development of the filial generation of mice to adulthood all took place under magnetic field exposure. The filial generation of mice was divided into four groups: 1) exposed females (n = 53), 2) exposed males (n = 53), 3) control group for females (n = 37) and 4) control group for males (n = 38). At the age of 31-35 weeks of age, the filial generation was examined.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: from gestation to 31-35 weeks of age

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration from gestation to 31-35 weeks of age
Exposure setup
Exposure source
Setup two circular coils of 0.375 m radius arranged in parallel planes separated by a distance equal to their radius; each coil had 220 turns of 1.2 mm-diameter copper wire; the common axis of the coil system was oriented east-west
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 15 µT effective value - - -
Additional parameter details

mice of the control groups exposed only to the local geomagnetic field of approximately 44 µT

Reference articles

  • Vallejo D et al. (2012): Growth variations in OF1 mice following chronic exposure of parental and filial generations to a 15 µT, 50 Hz magnetic field
  • Vallejo D et al. (2001): A Hematological Study In Mice For Evaluation Of Leukemogenesis By Extremely Low Frequency Magnetic Fields
  • Picazo ML et al. (1995): Effects of ELF Magnetic Fields on Hematological Parameters: An Experimental Model

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Exposed females (group 1) showed a significant shortening of the activated partial thromboplastin time, prothrombin time and reptilase time compared to the female control group (group 3). Moreover, there were several differences between the sexes unrelated to the magnetic field exposure.
The authors conclude that prenatal and postnatal exposure to a 50 Hz magnetic field might increase the blood coagulation in female mice, probably due to changes in the composition of fibrinogen.

Study character:

Study funded by

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