EMF-Portal | Influence of microwaves on different types of receptors and the role of peroxidation of lipids on receptor-protein shedding

Influence of microwaves on different types of receptors and the role of peroxidation of lipids on receptor-protein shedding med./bio.

By: Philippova TM, Novoselov VI, Alekseev SI

Published in: Bioelectromagnetics 1994; 15 (3): 183-192

Aim of study (acc. to author)

To investigate the effects of microwave exposure of rat chemoreceptors in vitro. In this context also the role of lipid peroxidation on protein shedding was examined.

Endpoint

cell function: effects on different types of receptors; role of lipid peroxidation on protein shedding

Exposure

Exposure	Parameters
Exposure 1: 900 MHz Modulation type: CW Exposure duration: continuous for 15 min	SAR: 18 W/kg mean (0.5, 1, 4, 12, and 18 W/kg) SAR: 90 W/kg peak value (2.5-90 W/kg)
Exposure 2: 900 MHz Modulation type: pulsed Exposure duration: continuous for 15 min	SAR: 18 W/kg mean (0.5, 1, 4, 12, and 18 W/kg) SAR: 90 W/kg peak value (2.5-90 W/kg)

Modulation type	CW

Exposure source	waveguide TE₀₁ mode
Chamber	A steady-state exposure temperature of 4 °C was achieved by water circulating around the glass exposure tube.
Additional info	In most of the experiments, samples were exposed for 15 min.

Measurand	Value	Type	Method	Mass	Remarks
SAR	18 W/kg	mean	measured and calculated	-	0.5, 1, 4, 12, and 18 W/kg
SAR	90 W/kg	peak value	measured and calculated	-	2.5-90 W/kg

SARs were determined using a glass exposure cell as described in detail elsewhere [Bolshakov and Alekseev, 1992].

Modulation type	pulsed
Duty cycle	20 %
Repetition frequency	100 Hz
Pulse type	rectangular
Additional info	Pulse repetition rate was 1, 6, 16, 32, 75, or 100 pps.

Exposure source	same setup as exposure 1

Measurand	Value	Type	Method	Mass	Remarks
SAR	18 W/kg	mean	measured and calculated	-	0.5, 1, 4, 12, and 18 W/kg
SAR	90 W/kg	peak value	measured and calculated	-	2.5-90 W/kg

Bolshakov MA et al. (1992): Bursting responses of Lymnea neurons to microwave radiation
Philippova TM et al. (1988): Microwave effect on camphor binding to rat olfactory epithelium

Methods Endpoint/measurement parameters/methodology

Investigated system:

Time of investigation:

Main outcome of study (acc. to author)

Microwave exposure affected the ligand/cell membrane binding in different manner. The binding of glutamic acid to hippocampal cells was not altered, whereas the binding of dihydroalprenolol to liver cell membranes was fivefold decreased. Also the binding of camphor to the olfactory membrane fraction was decreased up to 80%. Microwave exposure did not cause an accumulation of products from the lipid peroxidation.

Study character:

Study funded by

not stated/no funding