The effects of exposure of rats to a 50 Hz magnetic field on ultrastructure and apoptosis in the hippocampus should be investigated.
24 rats were divided into two groups (n=12 each): 1) exposure to the magnetic field and 2) control group.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
4 hours/day for 10 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | 4 hours/day for 10 weeks |
| Exposure source | |
|---|---|
| Setup | the system consisted of 2 windings of opposite direction which produced a uniform field in the center of the device where animals were located |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 3 mT | - | - | - | - |
In ultrastructural investigations, hippocampus samples of exposed rats showed some glial cells with a dense core and compact chromatin and mitochondria with vague cristae. Nerve cells in the exposure group were damaged, with compact chromatin and a decreased amount of intracellular organelles. Moreover, vacuoles were visible and intracellular organelles such as the mitochondria were morphologically abnormal and uncertain. In the control group, these features were not detected.
The number of apoptotic cells was significantly increased in the exposure group compared to the control group.
The authors conclude that exposure to a 50 Hz magnetic field might change the ultrastructure and increase apoptosis in the hippocampus of rats.
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