Study type: Medical/biological study (experimental study)

Evaluation of potential health effects of 10 kHz magnetic fields: a short-term mouse toxicology study med./bio.

Published in: Bioelectromagnetics 1996; 17 (2): 111-122

Aim of study (acc. to author)

To evaluate possible health effects of 10 kHz sinusoidal magnetic field on animal health. A preliminary 14 day acute study and a 90 day subchronic study were conducted.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 10.2 kHz
Exposure duration: repeated daily exposure, c.a 22.6 h/day for 14 days
Exposure 2: 10.2 kHz
Exposure duration: repeated daily exposure, c.a 22.6 h/day for 90 days

Exposure 1

Main characteristics
Frequency 10.2 kHz
Type
Waveform
Exposure duration repeated daily exposure, c.a 22.6 h/day for 14 days
Exposure setup
Exposure source
Chamber The exposure room was lined with 0.9 mm thick aluminum (double layer for walls near the benches). Ambient temperature and relative humidity in the exposure room was maintained at 21°C and 50%, respectively.
Setup Mice housed in cages, containing no metal parts, which were placed on wooden benches on which the coils were fitted. The cages were rotated daily.
Additional info The control bench was shielded with 0.9 mm thick aluminium on all four sides to a height of 1500 mm above the floor (700 mm above the bench) but no shielding was placed over the bench to avoid affecting the lightning and temperature of the control animals. The average air temperature were 21°C, 23°C, 23.5°C and 24°C for control, low field, medium field and high field benches.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified measured - high field
magnetic flux density 280 µT unspecified measured - medium magnetic field
magnetic flux density 100 µT unspecified measured - low magnetic field

Exposure 2

Main characteristics
Frequency 10.2 kHz
Type
Waveform
Exposure duration repeated daily exposure, c.a 22.6 h/day for 90 days
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified measured - high field
magnetic flux density 280 µT unspecified measured - medium magnetic field
magnetic flux density 100 µT unspecified measured - low magnetic field

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

These investigations failed to demonstrate any health effects that can be clearly related to the magnetic field exposure. No alterations in behaviour or indications of morbidity were detected during the initial exposure. There were no significant differences in body weight between exposed and unexposed animals at any time in the study. The clinical chemistry and hematology parameters were essentially unchanged.
Although minor differences in some clinical chemistry and hematology parameters were found between control and exposure groups, the lack of exposure dependence, the lack of consistency between sexes, and the lack of correspondence with the data of the two studies all suggest that these were chance associations.
Finally, all organs were normal except for isolated, generally mild, histological lesions and lesions that were ascribed to fighting among males. There was no obvious association with field intensity.

Study character:

Study funded by