Study type: Medical/biological study (experimental study)

Effect of rosmarinic acid on sertoli cells apoptosis and serum antioxidant levels in rats after exposure to electromagnetic fields med./bio.

By: Hajhosseini L, Khaki A, Merat E, Ainehchi N
Published in: Afr J Tradit Complement Altern Med 2013; 10 (6): 477-480
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Aim of study (acc. to author)

To study the effect of electromagnetic field exposure and rosmarinic acid administration on Sertoli cells.

Background/further details

40 rats were divided into 4 groups (each group n=10): 1) control group, 2) rosmarinic acid administration alone (5 mg/rat or kg body weight (varying information) daily for 6 weeks), 3) electromagnetic field exposure, 4) electromagnetic field exposure + rosmarinic acid administration.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 42 days (or 4 weeks; varying information)

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 42 days (or 4 weeks; varying information)
Exposure setup
Exposure source
Setup two copper coils placed one above the other in a distance of 50 cm; a cylindrical wooden vessel was placed between the coils (exposure area), the interior of which contained a chamber for holding the cage with the animals; 4 cages at a time were placed within the chamber, with ten rats per cage (remark EMF-Portal: make no sense in view of the group description?!)
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 8 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Malondialdehyde level significantly decreased in the group that received rosmarinic acid alone (group 2) in comparison to the control group and increased in the exposure group (3) compared to the control group. Sertoli cells apoptosis was increased in all groups in comparison to the control group, but only significant in the exposure groups 3 and 4. Level of testosterone and total antioxidant capacity significantly increased in the group (2) that received rosmarinic acid alone compared to the control group. In contrast, testosterone level significantly decreased in the exposure group (3) compared to the control group.
The authors conclude that rosmarinic acid as food additive could be effective for supporting people living under electromagnetic field environmental pollution.

Study character:

Study funded by

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