Study type: Medical/biological study (experimental study, review/survey)

Review of studies on modulating enzyme activity by low intensity electromagnetic radiation med./bio.

By: Vojisavljevic V, Pirogova E, Cosic I
Published in: 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, Buenos Aires, Argentina. IEEE, 2010: pp. 835-838; ISBN 978-1-4244-4123-5
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Aim of study (acc. to author)

To study the effects of non-thermal low level microwaves, of light (550-850 nm) and near infrared radiation (1140-1200 nm) exposures on L-lactate dehydrogenase enzyme activity. The publication is a compilation of previous findings on non-thermal effects of electromagnetic irradiation at the molecular level.

Background/further details

In the EMF-Portal summary only the microwave effects are listed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 400–975 MHz
Exposure duration: continuous for 240 s

Exposure 1

Main characteristics
Frequency 400–975 MHz
Type
Exposure duration continuous for 240 s
Additional info in 25 MHz steps
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 0.02135 V/m - - - -
electric field strength 0.06754 V/m - - - -
electric field strength 0.21358 V/m - - - -
electric field strength 0.675 V/m - - - -
electric field strength 2.136 V/m - - - -
power density 0.0000012 W/m² - - - -
power density 0.000012 W/m² - - - -
power density 0.00012 W/m² - - - -
power density 0.0012 W/m² - - - -
power density 0.012 W/m² - - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

The data showed that applied low intensity electromagnetic irradiation could induce some frequency specific alterations in conformation of the enzyme lactate dehydrogenase.
L-lactate dehydrogenase enzyme activity increased by 5-10% using low intensity microwaves at 500-525 MHz (for electric fields of 0.021-2.14 V/m). 900 MHz irradiation increased lactate dehydrogenase enzyme activity for electric fields in the range of 0.021-0.068 V/m and decreased enzyme activity if the field was stronger than 0.67 V/m. A slight inhibiting effect on enzyme activity at the frequencies of 650 MHz (0.214 V/m), 700 MHz (0.68-2.14 V/m) and for 875-925 MHz (0.68-2.14 V/m) was observed, when lactate dehydrogenase activity was decreased by 2-15%. In summary, the maximum increase in lactate dehydrogenase activity was observed at the two particular frequencies 500 MHz and 900 MHz.
These observed biological effects can be explained by possible resonant effects produced by the external electromagnetic irradiation at the molecular level.

Study character:

Study funded by

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