Study type: Medical/biological study (experimental study)

Low intensity microwave radiation as modulator of the L-lactate dehydrogenase activity med./bio.

By: Vojisavljevic V, Pirogova E, Cosic I
Published in: Med Biol Eng Comput 2011; 49 (7): 793-799
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Aim of study (acc. to author)

To study the effects of non-thermal low level microwave exposure on L-lactate dehydrogenase enzyme activity.

Background/further details

The measurements were repeated five times for each experimental setting (frequency and intensity).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 400–975 MHz
Exposure duration: continuous for 240 s

Exposure 1

Main characteristics
Frequency 400–975 MHz
Type
Exposure duration continuous for 240 s
Additional info in steps of 25 MHz
Exposure setup
Exposure source
Setup 0.22 m long wide band TEM cell with absorber termination; cuvette with test solution placed inside the TEM cell, 22 cm from its top with the cuvette's long axis in direction of the E-field
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 0.02135 V/m - calculated - Power density: 0.0000012 W/m²
electric field strength 0.06754 V/m - calculated - Power density: 0.000012 W/m²
electric field strength 0.21358 V/m - calculated - Power density: 0.00012 W/m²
electric field strength 0.675 V/m - calculated - Power density: 0.0012 W/m²
electric field strength 2.136 V/m - calculated - Power density: 0.012 W/m²
Additional parameter details

for each frequency measurements were taken for the calculated electric fields and corresponding power densities

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

The data showed that L-lactate dehydrogenase enzyme activity selectively increased only by irradiation at the particular frequencies of 500 MHz (electric field: 0.021 V/m - 2.1 V/m) and 900 MHz (electric field: 0.021 - 0.21 V/m) and it decreased at 900 MHz when the electric field was stronger than 0.67 V/m.
The authors conclude that L-lactate dehydrogenase enzyme activity can be modulated by specific frequencies of low power microwave irradiation. This finding can serve to support the hypothesis that low intensity microwaves can induce non-thermal effects in biomolecules.

Study character:

Study funded by

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