Study type: Medical/biological study (experimental study)

Molecular mechanisms of microwave interactions with model ion channels med./bio.

By: Grigoriev PA, Pashovkin TV
Published in: J Biol Phys Chem 2006; 6 (4): 163-165
Journal partially peer-reviewed/peer-review process unclear
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Aim of study (acc. to author)

To study the effect of a 0.8 GHz electromagnetic field on alamethicin ion channel (cation-selective, voltage gated) in a lipid bilayer membrane.

Background/further details

The experiment was performed with a lipid bilayer membrane containing many (ca. 500) ion channels as well as with membranes containing only one channel.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 0.8 GHz
Exposure duration: continuous for 5 s

Exposure 1

Main characteristics
Frequency 0.8 GHz
Type
Exposure duration continuous for 5 s
Exposure setup
Exposure source
Setup Teflon cylinder with the BLM placed in a glass cuvette positioned in the center of the waveguide
Parameters
Measurand Value Type Method Mass Remarks
power 10 W - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The data showed that a 0.8 GHz electromagnetic field of 10 W power reversibly reduced the conductance of the model membrane (with many ion channels) to about 15% of its initial magnitude. The authors demonstrated that the observed effect of the electromagnetic field on the alamethicin ion channel can be explained by the rise of the local temperature of the membrane, and a concomitant redistribution of the ion channel conductance states.

Study character:

Study funded by

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