Study type: Medical/biological study (experimental study)

Microwave effects on acetylcholine-induced channels in cultured chick myotubes med./bio.

By: D'Inzeo G, Bernardi P, Eusebi F, Grassi F, Tamburello C, Zani BM
Published in: Bioelectromagnetics 1988; 9 (4): 363-372
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Aim of study (acc. to author)

To study the effects of microwaves on a membrane protein channel, the acetylcholine receptor-channel, in cultured chick myotubes.

Background/further details

Acetylcholine-induced currents have been recorded via patch-clamp techniques using both cell-attached (single-channel current recording) and whole-cell (total current recording) configurations.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 10.75 GHz
Modulation type: CW
Exposure duration: 30 s to 120 s

Exposure 1

Main characteristics
Frequency 10.75 GHz
Type
Exposure duration 30 s to 120 s
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.25 m
Parameters
Measurand Value Type Method Mass Remarks
power density 50 µW/cm² unspecified calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

During the exposure to low-power microwaves the frequency of the acetylcholine-activated single channel openings decreased, while the acetylcholine-induced total current showed a faster falling phase. Channel open time and conductance were not influenced by microwave exposure. The authors concluded that exposure to microwaves increases the rate of desensitization and decreases the channel opening probability.

Study character:

Study funded by

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