Medical/biological study (experimental study)

Changes of leukocyte adherence ability under the influence of magnetic field in the course of a treatment of patients with laryngeal and pharyngeal carcinoma med./bio.

By: Cocek A, Hahn A, Ambrus M, Dohnalova A, Jandova A, Pokorny J

Published in: Electromagn Biol Med 2008; 27 (3): 277-288

The adherence ability of T lymphocytes was generally examined in 52 patients with laryngeal and pharyngeal carcinoma between the year 2000 and 2005 (data not given in this extract).
Additionally, the values of non-adhering cells in T lymphocytes samples of the cancer patients in dependency of magnetic field exposure vs. no exposure were compared in vitro in the course of the oncological treatment.

Exposure	Parameters
Exposure 1: 50 Hz Exposure duration: continuous for 60 min	magnetic flux density: 0.5 mT maximum magnetic flux density: 0.1 mT magnetic flux density: 0.05 mT minimum

Exposure source	coil(s)
Setup	33 cm long coil with a diameter of 30 cm; test tubes with cells placed in the center of the coil

Measurand	Value	Type	Method	Mass	Remarks
magnetic flux density	0.5 mT	maximum	measured	-	-
magnetic flux density	0.1 mT	-	measured	-	-
magnetic flux density	0.05 mT	minimum	measured	-	-

Exposed system:

Investigated system:

Time of investigation:

The number of non-adherent T lymphocytes in was statistically significant lower under the influence of magnetic field exposure (T lymphocytes taken before the general oncological treatment as well as in the course of a successful treatment). There was no statistically significant difference between the effects with varying magnetic flux densities.
The magnetic field increased the adherence ability of T lymphocytes in patients with laryngeal and pharyngeal cancer in vitro.

Study character:

Cocek A et al. (2012): The impact of lower induction values of 50 Hz external electromagnetic fields on in vitro T lymphocyte adherence capabilities
Di Giampaolo L et al. (2006): Follow up study on the immune response to low frequency electromagnetic fields in men and women working in a museum
Jandova A et al. (2005): Effects of Magnetic Field 0.1 and 0.05 mT on Leukocyte Adherence Inhibition
Radeva M et al. (2004): Differences in lethality between cancer cells and human lymphocytes caused by LF-electromagnetic fields
Jandova A et al. (2004): Effects of Sinusoidal 0.5 mT Magnetic Field on Leukocyte Adherence Inhibition
Santini MT et al. (2003): Effects of a 50 Hz sinusoidal magnetic field on cell adhesion molecule expression in two human osteosarcoma cell lines (MG-63 and Saos-2)
Jandova A et al. (2001): Effects of sinusoidal magnetic field on adherence inhibition of leucocytes
Jandova A et al. (1999): Effects of sinusoidal magnetic field on adherence inhibition of leucocytes: preliminary results
Harland J et al. (1999): Evidence for a slow time-scale of interaction for magnetic fields inhibiting tamoxifen's antiproliferative action in human breast cancer cells