To study whether magnetic fields exposure additionally contribute to the convulsion mediated by the benzodiazepine-GABA complex receptor.
The onset and duration of convulsions induced by bicuculline alone or by co-exposure to magnetic fields and bicuculline were investigated.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
continuous for 6 h
|
|
Seven to ten rats were arranged in groups which were treated under the following conditions: i) sham exposure ii) exposure to magnetic field iii) sham exposure, treated with bicuculline methobromide iv) exposure to magnetic field, treated with bicuculline all drugs were administered after the MF exposure or in the sham
| Frequency | 60 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | continuous for 6 h |
| Exposure source |
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | unspecified | unspecified | - | - |
Magnetic fields strengthened the convulsion induced by bicuculline with a shortening of the onset time, but lengthening of the duration time. Co-exposure to magnetic fields and bicuculline decreased the GABA contents in the cortex, hippocampus and hypothalamus, whereas magnetic fields alone reduced the level of GABA only in the hippocampus.
These data indicate that the exposure to magnetic fields may modulate bicuculline-induced convulsions due to GABA neurotransmissions in rat brains.
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