EMF-Portal | Electromagnetic waves of 900 MHz in acute pentylenetetrazole model in ontogenesis in mice

Electromagnetic waves of 900 MHz in acute pentylenetetrazole model in ontogenesis in mice med./bio.

By: Erdinc OO, Baykul MC, Ozdemir O, Ozkan S, Sirmagul B, Oner SD, Ozdemir G

Published in: Neurol Sci 2003; 24 (3): 111-116

Aim of study (acc. to author)

To measure the effects of mobile phones on pentylenetetrazole (PTZ)-induced seizures in both prepubertal and adult mice. PTZ is known to impair GABA-mediated inhibition. Mice were exposed before an injection of PTZ.

Endpoint

Exposure

mobile communications
mobile phone

Exposure	Parameters
Exposure 1: 900 MHz Exposure duration: continuous for 2 h or 20 h	power: 0.25 mW

Exposure 1

Main characteristics

Frequency	900 MHz
Type	electromagnetic field
Exposure duration	continuous for 2 h or 20 h
Additional info	Erdinc OO, Baykul MC, Ozdemir AO, Ozkan S, Ozdemir G (1999) Effects of electromagnetic waves of 900 MHz in the pentylenetetrazol seizure model in mice. Epilepsia 40 S7:38 (abstract)

Exposure setup

Exposure source	dipole antenna λ/4 (8.3 cm), signal generator
Chamber	basket-box
Sham exposure	A sham exposure was conducted.
Additional info	After the exposure or sham exposure the mice were injected i.p. with 60 mg/kg of pentylenetetrazole (PTZ).

Parameters

Measurand	Value	Type	Method	Mass	Remarks
power	0.25 mW	-	measured	-	-

Measurement and calculation details

Power and frequency were tested with a spectrum analyser and a frequency-meter.

Exposed system:

animal
mouse
whole body

Methods Endpoint/measurement parameters/methodology

Investigated system:

investigation on living organism

Investigated organ system:

neuromuscular system

Time of investigation:

after exposure

Main outcome of study (acc. to author)

A statistically significant difference was found between the latency measurements within 20 h for prepubertal mice in stages 1 and 2 (stage 1: facial twitching, stage 2: mild myoclonic movements in the extremities). In these animals, latency was reduced. Between the other groups, no differences were revealed.The effects on prepubertal mice of long-term 900 MHz electromagnetic waves in a PTZ model may be an indication of possible problems in developing brains.

Study character:

medical/biological study
experimental study
full/main study

Study funded by

not stated/no funding

Kouchaki E et al. (2016): Effect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice

Cinar N et al. (2013): What is the impact of electromagnetic waves on epileptic seizures?

Carballo-Quintas M et al. (2011): A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900MHz in the picrotoxin model of rat brains

Koyama S et al. (2007): Effects of 2.45 GHz electromagnetic fields with a wide range of SARs on bacterial and HPRT gene mutations

Canseven AG et al. (2007): Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field