Study type: Medical/biological study (experimental study)

Pentylenetetrazol-induced seizures are not altered by pre- or post-drug exposure to a 50 Hz magnetic field med./bio.

By: Canseven AG, Keskil ZA, Keskil S, Seyhan N
Published in: Int J Radiat Biol 2007; 83 (4): 231-235
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Aim of study (acc. to author)

To study whether pre- and/or post-drug magnetic field exposure of 50 Hz (0.2 mT) has any significant effect on pentylenetetrazol-induced seizures in mice.

Background/further details

Seizures were induced by pentylenetetrazol injection (60 mg/kg). A total of 48 female mice were studied.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 30 min, 1 h or 1.5 h continuous

General information

mice were exposed in the following four groups: i) MF off + Pentylenetetrazol + MF off (sham) ii) MF on for 1 h + Pentylenetetrazol + MF on for 30 min iii) MF on for 1 h + Pentylenetetrazol + MF off iv) MF off + Pentylenetetrazol + MF on for 30 min

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 30 min, 1 h or 1.5 h continuous
Exposure setup
Exposure source
Setup pair of circular Helmholtz coils with a diameter of 42.75 cm and 145 turns of insulated copper wire each, with a common axis, 21.375 cm apart; mice placed in the center of the coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.2 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

Neither pre- nor post-drug exposure to a 50 Hz magnetic field (0.2 mT) had any effect on pentylenetetrazol-induced epileptic seizures or mortality rates in mice.
The data failed to provide any support for a therapeutic potential of a 50 Hz magnetic field (0.2 mT) for epilepsy.

Study character:

Study funded by

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