Enzymology. An enzyme that catalyses the conversion of arginine, NADPH, and oxygen to citrulline, nitric oxide, and NADP+. The expression of iNOS can be induced by cytokines (e.g., interferon-gamma, tumor necrosis factor, interleukin) whereas the two other types of NO synthases, namely nNOS and eNOS, are always present (constitutively expressed). The stimuli and conditions that determine iNOS expression are cell and species specific.
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