Neurophysiology. A potent inhibitor of the high-affinity choline uptake system. Since choline is a component of the neurotransmitter acetylcholine, treatment with hemicholinium-3 can stop the synthesis of acetylcholine in the synapse and deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is used as a research tool in animal and in vitro experiments.
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