Medical/biological study (observational study)

Comparison of chromosome aberration and micronucleus induction in human lymphocytes after occupational exposure to vinyl chloride monomer and microwave radiation med./bio.

By: Garaj-Vrhovac V, Fucic A, Horvat D

Published in: Period Biol 1990; 92 (4): 411-416

To compare the results of the lymphocyte micronucleus test and the chromosome aberration assay from subjects exposed to vinyl chloride monomer (VCM) or to microwave radiation. Blood samples of workers from a radar station service and from the polyvinylchloride industry were investigated.

Exposure	Parameters
Exposure 1: 200 kHz–26 GHz Exposure duration: repeated daily exposure	power density: 200 W/m² maximum power density: 10 µW/cm² minimum (50 µW/cm² max value.)

Frequency	200 kHz–26 GHz
Exposure duration	repeated daily exposure

Exposure source	Radar service station
Additional info	Occupational exposure of workers at a radar service station.

Measurand	Value	Type	Method	Mass	Remarks
power density	200 W/m²	maximum	measured	-	-
power density	10 µW/cm²	minimum	measured	-	50 µW/cm² max value.

Exposed system:

Investigated system:

Investigated organ system:

Time of investigation:

Both quantitative and qualitative differences between vinyl chlorid monomer (VCM) and microwave radiation in the induction of aberrations and micronuclei were detected. VCM causes quantitatively more chromosome damage but less dicentric and ring chromosomes than microwave exposition. Anaphase bridges are present in the cultured lymphocytes of VCM-exposed persons but they are rarely seen in the lymphocytes of microwave-exposed persons. The number of micronuclei per a certain number of aberrations is much higher in persons exposed to VCM than those exposed to microwaves.

Study character:

Garaj-Vrhovac V et al. (2011): Assessment of cytogenetic damage and oxidative stress in personnel occupationally exposed to the pulsed microwave radiation of marine radar equipment
Yildirim MS et al. (2010): Effect of mobile phone station on micronucleus frequency and chromosomal aberrations in human blood cells
Hintzsche H et al. (2010): Micronucleus frequency in buccal mucosa cells of mobile phone users
Yadav AS et al. (2008): Increased frequency of micronucleated exfoliated cells among humans exposed in vivo to mobile telephone radiations
Manti L et al. (2008): Effects of modulated microwave radiation at cellular telephone frequency (1.95 GHz) on X-ray-induced chromosome aberrations in human lymphocytes in vitro
Ferreira AR et al. (2006): Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring
Gandhi G et al. (2005): Genetic damage in mobile phone users: some preliminary findings
Koyama S et al. (2004): Effects of 2.45-GHz electromagnetic fields with a wide range of SARs on micronucleus formation in CHO-K1 cells

This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.