Study type: Medical/biological study (experimental study)

[Cell proliferation, sister chromatid exchanges, chromosome aberrations, micronuclei, and mutation rate of HGPRT-locus] med./bio.

Zellproliferation, Schwesterchromatidaustausche, Chromosomenaberrationen, Mikrokerne und Mutationsrate des HGPRT-Locus

By: Eberle P, Erdtmann-Vourliotis M, Diener S, Finke HG, Löffelholz B, Schnor A, Schräder M
Published in: Edition Wissenschaft 1996; 4: 2-15
Journal not peer-reviewed
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Aim of study (acc. to author)

To determine whether high-frequency electromagnetic fields, such as those generated during the use of mobile phones, have a carcinogenic effect. It was examined whether mutations occurred in genes and chromosomes and whether there were any changes in cell growth.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 440 MHz
Exposure duration: continuous for 70, 50, or 39 h
Exposure 2: 440 MHz
Exposure duration: continuous for 30 h of RF followed by 40 or 20 h of 50 Hz
Exposure 3: 440 MHz
Exposure duration: continuous for 30 h of 50 Hz followed by 40 h of RF
Exposure 4: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 70 or 50 h
Exposure 5: 900 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 8 h of RF followed by 16 h of 50 Hz, for a total of 70 or 50 h
Exposure 6: 1.8 GHz
Modulation type: pulsed
Exposure duration: continuous for 70 or 50 h

Exposure 1

Main characteristics
Frequency 440 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 70, 50, or 39 h
Exposure setup
Exposure source
Setup Up to nine test tubes could be placed in a sample holder made of Plexiglas and placed below or above the septum. The tubes were circulated by white oil maintained at 37 ± 0.1 °C.
Parameters
Measurand Value Type Method Mass Remarks
power 2 W - - - -
electric field strength 20 V/m - - - -
magnetic flux density 67 nT - - - in the empty cell

Exposure 2

Main characteristics
Frequency 440 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 30 h of RF followed by 40 or 20 h of 50 Hz
Additional info 50 Hz MF was also used.
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power 2 W - - - -
electric field strength 20 V/m - - - -
magnetic flux density 1 µT - - - 50 Hz

Exposure 3

Main characteristics
Frequency 440 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 30 h of 50 Hz followed by 40 h of RF
Additional info 50 Hz MF was also used.
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power 2 W - - - -
electric field strength 20 V/m - - - -
magnetic flux density 1 µT - - - 50 Hz

Exposure 4

Main characteristics
Frequency 900 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 70 or 50 h
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Additional info

pulse period of 4.615 ms
Exposure setup
Exposure source
Setup Up to six test tubes could be exposed in the GTEM cell.
Parameters
Measurand Value Type Method Mass Remarks
power 5 W - - - -
electric field strength 66 V/m - - - -

Exposure 5

Main characteristics
Frequency 900 MHz
Type
Charakteristic
  • guided field
Exposure duration repeated daily exposure, 8 h of RF followed by 16 h of 50 Hz, for a total of 70 or 50 h
Additional info 50 Hz MF was also used.
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Additional info

pulse period of 4.615 ms
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power 5 W - - - -
electric field strength 66 V/m - - - -
magnetic flux density 1 µT - - - 50 Hz

Exposure 6

Main characteristics
Frequency 1.8 GHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 70 or 50 h
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Additional info

pulse period of 4.615 ms
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power 5 W - - - -
electric field strength 66 V/m - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

There were no indications that the examined parameters were effected by the high-frequency electromagnetic fields.

Study character:

Study funded by

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