Study type: Medical/biological study (experimental study)

Effects of static magnetic field on human leukemic cell line HL-60 med./bio.

By: Sabo J, Mirossay L, Horovcak L, Sarissky M, Mirossay A, Mojzis J
Published in: Bioelectrochemistry 2002; 56 (1-2): 227-231
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Aim of study (acc. to author)

To investigate the effects of strong static magnetic fields (SMF) on metabolic activity of human leucemic cell line HL-60 in the presence or absence of antineoplasic drugs.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: 72 h

Exposure 1

Main characteristics
Frequency
Type
Exposure duration 72 h
Exposure setup
Exposure source
Chamber incubator
Additional info Hemogenous field achieved between the ring pole caps as the gap was relatively small (2 cm) compared with the face diameter of the poles (10 cm).
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 T maximum measured unspecified -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Without drug treatment, SMF exposed cells showed a decreased metabolic activity as compared with sham exposed, untreated control cells. Under conditions of combined SMF exposure and treatment with different mixtures of antineoplastic drugs a statistically significant reduced metabolic activity could be observed for some of the mixtures. But the cytotoxic drug effect was enhanced due to SMF exposure in all concentration mixtures used. So, the results show that SMF has a pronounced effect on metabolic activity of human leukemic cell line HL-60.

Study character:

Study funded by

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