Study type: Medical/biological study (experimental study)

DNA structural changes caused by microwave radiation med./bio.

By: Sagripanti JL, Swicord ML
Published in: Int J Radiat Biol Relat Stud Phys Chem Med 1986; 50 (1): 47-50
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Aim of study (acc. to author)

To investigate the microwave absorption properties of plasmid DNA molecules of homogeneous size with the surprising observation of resonant absorption by the molecules in aqueous solution. Physicochemical changes in plasmids exposed to the resonant frequency were investigated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.55 GHz
Modulation type: CW
Exposure duration: continuous for 20 min
  • SAR: 0 mW/g minimum (0 - 8.5 mW/g)
  • SAR: 8.5 mW/g maximum
  • SAR: 21 mW/g minimum (21 - 85 mW/g)
  • SAR: 85 mW/g maximum
Exposure 2: 10 kHz
Modulation type: CW
Exposure duration: continuous for 20 min
-

Exposure 1

Main characteristics
Frequency 2.55 GHz
Type
Exposure duration continuous for 20 min
Modulation
Modulation type CW
Exposure setup
Exposure source
  • open-ended copper coaxial probe, 4 mm diameter, immersed 1mm into the 3 mm deep sample
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0 mW/g minimum estimated - 0 - 8.5 mW/g
SAR 8.5 mW/g maximum estimated - -
SAR 21 mW/g minimum estimated - 21 - 85 mW/g
SAR 85 mW/g maximum estimated - -

Exposure 2

Main characteristics
Frequency 10 kHz
Type
Exposure duration continuous for 20 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The work reports an observed power-dependent and temperature-independent effect of microwaves on isolated DNA molecules in solution. Exposure at or near the resonant frequency resulted in single- and double-strand breaks of supercoiled plasmid DNA as shown by an accompanying increase in the amount of relaxed and linear forms of the molecule, respectively.

Study character:

Study funded by

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