Study type: Medical/biological study (experimental study)

Hematopoietic neoplasia in C57BL/6 mice exposed to split-dose ionizing radiation and circularly polarized 60 Hz magnetic fields med./bio.

By: Babbitt JT, Kharazi AI, Taylor JM, Bonds CB, Mirell SG, Frumkin E, Zhuang D, Hahn TJ
Published in: Carcinogenesis 2000; 21 (7): 1379-1389
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Aim of study (acc. to author)

To investigate the effects of magnetic field exposure on the development of cancer induced by ionizing radiation in femal mice.

Background/further details

Mice were treated wit three different levels of ionizing radiation (total doses of 3 Gy, 4 Gy, and 5.1 Gy, applied weekly in one quarter split doses). Chronic magnetic field exposure (1.42 mT) was started at the first day of gamma radiation

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: lifetime exposure, 18 h/day

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Polarization
  • circular
Exposure duration lifetime exposure, 18 h/day
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.42 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Mortality rate was not increased by magnetic field exposure. The relative incidences of hematopoietic neoplasms were not changed between exposed and sham-exposed control groups. A marginally significant reduction of relative risk for lymphoblastic lymphoma were observed in mice exposed to 5.1 Gy and magnetic field.

Study character:

Study funded by

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