To study if teratological changes occur in rat pups as a result of (1) daily ultra wideband exposures during gestation days 3-18, or (2) as a result of both prenatal and postnatal (10 days) exposures.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
0.1–1 GHz
Modulation type:
pulsed
Exposure duration:
repeated daily exposure for 2 min, see add. information
|
|
| Frequency | 0.1–1 GHz |
|---|---|
| Type | |
| Waveform | |
| Charakteristic |
|
| Exposure duration | repeated daily exposure for 2 min, see add. information |
| Modulation type | pulsed |
|---|---|
| Pulse width | 1.8 ns |
| Rise time | 300 ps |
| Repetition frequency | 1,000 Hz |
| Exposure source |
|
|---|---|
| Setup | Each rat was lightly restrained within a cylindrical Plexiglas™ holder that was placed within a custom-made parallel transmission plate exposure system with the long axis of the body parallel to the K-vector of the propagating field. |
| Sham exposure | A sham exposure was conducted. |
| Additional info | Dams were exposed during gestation days 3 to 18 either to UWB or sham irradiation or, as a positive control, to lead (Pb) acetate solution (2 g/l) continuously available in the drinking water. The second exposure regimen group received the same prenatal exposures, but in addition, the pups were postnatally exposed (UWB, sham, or Pb acetate) from day 1 to 10. The Pb-exposed rats were transported to and from the UWB exposure facility, but were not placed inside the parallel plates. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 55 kV/m | peak value | measured | - | - |
| SA | 0.45 mWs/kg | peak value | calculated | - | - |
| SAR | 45 mW/kg | mean | estimated | whole body | dams |
Behavioral, functional, and morphological effects of ultra wideband irradiation were unremarkable with these exceptions: (1) The exposed pups emitted significantly more stress vocalizations than the sham-exposed pups; (2) the medial-to-lateral length of the hippocampus was significantly longer in the exposed animals than in the sham-exposed pups; (3) male offspring exposed in utero mated significantly less frequently than sham-exposed males, but when they did mate there was no difference in fertilization and offspring numbers from the sham-exposed group.
There does not appear to be a unifying physiological or behavioral relationship among the significant differences revealed, and the data could be due to the expected spurious results derived when a large number of statistical comparisons are made.
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