To investigate light-dependent behavioral effects of extremely low frequency magnetic field exposure on opioid mediated analgesia in the land snail Capaea nemoralis.
The administration of SCH34826, a selective inhibitor of the enzyme enkaphilinase, caused an increased enkephalin activity, which results again in an enhanced response latency in the foot-lifting behaviour onto a thermal stimulus (applied by a hotplate).
q.v. publication 4768
| Exposure | Parameters |
|---|---|
|
Exposure 1:
0–30 Hz
Exposure duration:
15 min
|
|
|
Exposure 2:
0–60 Hz
Exposure duration:
15 min
|
|
|
Exposure 3:
0–120 Hz
Exposure duration:
15 min
|
|
Four groups of snails were used: sham light, sham dark, expoed light and exposed dark.
| Frequency | 0–30 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 15 min |
| Additional info | Sinusoidal signal was superimposed on the DC signal. |
| Exposure source | |
|---|---|
| Setup | 40 cm x 40 cm animal holder platform was positioned at the center of the x and y axis of the coils, 10 cm below the center of the z-coil. |
| Additional info | Snails were exposed either in the presence or absense of light. In light conditions, snails were placed into translucent plastic containers made up of identical top and bottom halves (12 cm² x 5 cm high). In dark conditions, the top and bottom plastic containers were covered with black electric tape. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 39.1 µT | - | measured | - | DC magnetic field. |
| magnetic flux density | 70.5 µT | peak value | measured | - | time varying magetic field. |
| Frequency | 0–60 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 15 min |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 141 µT | peak value | measured | - | time varying magetic field. |
| magnetic flux density | 78.1 µT | - | measured | - | DC magnetic field. |
| Frequency | 0–120 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 15 min |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 282 µT | peak value | measured | - | time varying magetic field. |
| magnetic flux density | 156.2 µT | - | measured | - | DC magnetic field. |
Magnetic field exposure leads to a reduction of opioid-induced analgesia. Light exposure at the same time significantly enhanced this effect rather than MF-exposure in the dark. But the percentage of reduction in analgesia was found to be independent of the frequency of the applied magnetic fields. The latter observation suggest a direct magnetic field detecting mechanism.
This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.
