To study the combined in vitro effects of microwaves and hyperthermia on the ability of normal B lymphocytes to cap surface immunoglobulin (Ig).
Normal mouse B lymphocytes were tested following exposure to 2.45-GHz (continuous wave (CW)) at 37, 41, and 42.5°C.
Exposure | Parameters |
---|---|
Exposure 1:
2.45 GHz
Modulation type:
CW
Exposure duration:
30 min
|
|
Exposure 2:
2.45 GHz
Modulation type:
CW
Exposure duration:
10 min
|
|
Frequency | 2.45 GHz |
---|---|
Exposure duration | 30 min |
Modulation type | CW |
---|
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
power density | 50 W/m² | minimum | - | - | 10 mW/cm², 25 mW/cm², 50 mW/cm² and 100 mW/cm² |
Frequency | 2.45 GHz |
---|---|
Exposure duration | 10 min |
Modulation type | CW |
---|
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
power density | 50 W/m² | minimum | - | - | 10 mW/cm², 25 mW/cm², 50 mW/cm² and 100 mW/cm² |
The data show that for the nonirradiated controls, capping is reduced from 90% at 37°C, to 52% at 41°C, to less than 5% for cells that were pretreated at 42.5°C. There was no significant difference between the exposed cells and the control cells when both were maintained at the same temperature. In another experiment (field 2), there was no significant difference in the percentage of capping between control cells and cells that were exposed to microwave irradiation during capping, when the temperature in both preparations was kept at 38.5°C.
The data indicate that the mechanism responsible for inhibition of capping are thermal in origin. Further studies are needed to examine what cellular components are affected by heat, resulting in inhibition of capping, and what would be the physiological significance of such inhibition at temperatures often associated with fever and hyperthermia.
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