Study type:
Epidemiological study
(observational study)
Prospective study of occupation and amyotrophic lateral sclerosis mortality
epidem.
By:
Weisskopf MG, McCullough ML, Morozova N, Calle EE, Thun MJ, Ascherio A
Published in: Am J Epidemiol 2005; 162 (12): 1146-1152
Aim of study (acc. to author)
Further details
Occupations were categorized according to the 1980 Bureau of the Census occupational titles and were assigned to one of 13 broad occupational groups.
Endpoint/type of risk estimation
Exposure
Assessment
- questionnaire: at baseline, current occupation, the job held for the longest period of time, and the years spent working in each
Population
-
Group:
-
Characteristics:
participants of the Cancer Prevention Study II of the American Cancer Society
-
Observation period:
1982 - 2002, follow-up 1989 - 2002
-
Study location:
USA
-
Data source:
National Death Index
-
Exclusion criteria:
persons with missing occupational data, persons with major illness at baseline, persons who died before 1989
Study size
| Type |
Value |
| Total |
1,184,561 |
Statistical analysis method:
- Cox proportional regressions analysis
(
adjustment:
- age
- education
- smoking, alcohol intake, military service
)
Results (acc. to author)
Overall, 507 deaths from amyotrophic lateral sclerosis were observed during 4,913,369 person-years among men and 430 deaths during 7,081,569 person-years among women.
No association between death from amyotrophic lateral sclerosis and the occupations of electrician, welder, or farmer, each of which has been associated with amyotrophic lateral sclerosis in previous studies, was observed in this prospective study. Among men, increased amyotrophic lateral sclerosis mortality was found for programmers (RR 4.55, CI 1.46-14.2) and laboratory technicians (RR 1.96, CI 1.04-3.66). Among women, elevated amyotrophic lateral sclerosis mortality was observed for machine assemblers (RR 2.81, CI 1.05-7.53) and a marginally significant increase was found for nurses (RR 1.40, CI 0.96-2.04). These results were based on a small number of cases in each occupational category, however, and should be interpreted cautiously.
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