To determine if 1) radiofrequency radiation (RFR) alone (2450 MHz, pulsed wave) can induce sister chromatid exchange (SCE) formation in Chinese hamster ovary cells, and 2) RFR during simultaneous treatment with mitomycin C (MMC) under the same conditions can cause a change in frequency in SCEs beyound that which is produced by the MMC alone.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
2.45 GHz
Modulation type:
pulsed
Exposure duration:
up to 3 h
|
|
cells were treated in the following groups: i) control ii) EMF iii) Mitomycin (MMC) added iv) EMF + MMC v) sham
| Frequency | 2.45 GHz |
|---|---|
| Type | |
| Exposure duration | up to 3 h |
| Modulation type | pulsed |
|---|---|
| Pulse width | 10 µs |
| Duty cycle | 25 % |
| Repetition frequency | 25 kHz |
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 1.6 m |
| Setup | 12.2 m x 6.1 m x 3.1 m anechoic chamber; exposuer flasks in water bath |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 49 mW/cm² | spatial average | measured | - | - |
| SAR | 33.8 W/kg | - | calculated | - | - |
1) Pulsed wave RFR at the specific field parameters (i.e. at a moderate power density and SAR) has no effect on sister chromatid exchange (SCE) induction in CHO cells, and is unlikely to be genotoxic. 2) A simultaneous treatment with MMC and RFR did nor result in an increase SCE frequency over that caused by MMC treatment alone.
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