To investigate whether the exposure to an extremely low frequency magnetic field affects the behavior of Mongolian gerbils submitted to global cerebral ischemia.
Cerebral ischemia was induced by surgical occlusion of both common carotid arteries for 10 min. Adult (3-month-old) male gerbils were divided into four groups (6-8 animals/group): 1.) control, 2.) exposure, 3.) ischemia, and 4.) ischemia + exposure. The control group was further subdivided into intact controls, sham operated, and sham exposed animals.
The behavioral parameters were investigated on days 1, 2, 4, and 7 of exposure (immediate effect) and seven days after exposure (day 14, delayed effect).
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
continuous for 7 days
|
|
animals were divided into the following four groups: i) control ii) exposure to EMF iii) ischemia iv) ischenia + exposure to EMF
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | continuous for 7 days |
| Exposure source |
|
|---|---|
| Setup | two 26 cm x 43 cm x 15 cm polycarbonate cages with 3 - 4 animals each, positioned on both sides of the electromagnet so that the center of the cage was at a distance of 20 cm from the pole |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 0.2 mT | minimum | measured | - | at the end of the cage with the greatest distance to the pole |
| magnetic flux density | 2 mT | maximum | measured | - | at the end of the cage with the smallest distance to the pole |
| magnetic flux density | 0.5 mT | spatial average | measured | - | at the center of the cage |
The 10-min global cerebral ischemia per se induced a significant increase of motor activity, stereotypy and rotations, and consequently immobility decrease until day 4 in ischemic animals compared to control gerbils. Exposure to an extremely low frequency magnetic field per se showed a tendency of increasing motor activity (data not shown).
Exposure to an extremely low frequency magnetic field + ischemia (group 4) inhibited the development of ischemia-induced motor hyperactivity during the whole period of monitoring, particularly in the first two days after reperfusion, when the post-ischemic hyperactivity was most evident.
The authors concluded that the exposure to an extremely low frequency magnetic field decreased motor hyperactivity induced by the 10-min global cerebral ischemia.
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