To study the effects of combined exposure to CDMA and WCDMA radiofrequency electromagnetic fields on lymphoma development in a lymphoma mouse model.
160 mice (80 male and 80 female) were divided into four groups (each group n=40): 1) male mice, sham exposed, 2) male mice, exposed, 3) female mice, sham exposed, 4) female mice, exposed.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
848.5–1,950 MHz
Exposure duration:
continuous for 45 min/day, 5 days/week for up to 42 weeks
|
Mice were treated in four groups: i) male, sham exposed ii) male, exposed iii) female, sham exposed iv) female, exposed
| Exposure source |
|
|---|---|
| Chamber | 2.29 m x 2.29 m x 1.47 m reverberation chamber, 2.3 mm thickness of wall |
| Setup | 215 mm x 320 mm x 130 mm cages placed on a 1.32 m x 1.32 m x 0.7 m wooden table inside the chamber; 5 mice per cage |
| Sham exposure | A sham exposure was conducted. |
| Additional info | the article contains unclear information on the number of cages exposed simultaneously (4 or 8) |
No differences were found in final survival, lymphoma incidence, and splenomegaly incidence between sham exposed and radiofrequency exposed mice. However, occurrence of metastasis infiltration to the brain in lymphoma-bearing mice was significantly different in radiofrequency exposed mice when compared to sham exposed mice, even though no consistent correlation was observed between male and female mice (increase in female mice, but decrease in male mice). However, infiltration occurrence to liver, lung, and spleen was not different between the groups.
The authors conclude that simultaneous exposure to CDMA and WCDMA radiofrequency electromagnetic fields did not affect lymphoma development in AKR/J mice.
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