To study nociceptive responses to different noxious stimuli in growing rats exposed to a chronic intermittent radiofrequency field (73,5 MHz, 45 days).
Investigating the nociceptive status of an organism to a variety of noxious stimuli under radiofrequency exposure is of importance for setting exposure guidelines.
Male rats were assigned to a radiofrequency exposure group and to a control group. After chronic exposure, paw lick latency was first tested in unrestrained rats: (a) phasic pain, hot plate. After a rest of 4 h, rats were restrained for determination of threshold of pain: (b) electrical stimuli of varying current strength. On day two the tonic pain was studied: (c) injection of formalin into the paw.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
73.5 MHz
Modulation type:
AM
Exposure duration:
2 h/day for 45 days
|
|
| Frequency | 73.5 MHz |
|---|---|
| Type | |
| Exposure duration | 2 h/day for 45 days |
| Modulation type | AM |
|---|---|
| Modulation frequency | 15 Hz |
| Exposure source | |
|---|---|
| Setup | 32 cm x 10 cm x 9 cm plexiglas cages |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 70.71 V/m | - | calculated | - | - |
| power density | 1.33 mW/cm² | - | calculated | - | - |
| SAR | 0.4 W/kg | - | calculated | whole body | - |
In radiofrequency exposed rats, the response to tonic pain was attenuated (c); the latency of tail flick was not affected (a); and the latency of response to hot plate decreased (a). The threshold of tail flick and simple vocalization were not affected while the threshold of vocalization after stimulus decreased (b).
The results suggest a decreased response to tonic pain indicating analgesia and a decreased threshold of vocalization after discharge indicating an exaggerated emotional response to painful stimuli. Radiofrequency fields differentially affect the mechanisms involved in the processing of various noxious stimuli.
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