Medical/biological study (experimental study)

Effect of low-intensity extremely high frequency radiation on reproductive function in wistar rats med./bio.

By: Subbotina TI, Tereshkina OV, Khadartsev AA, Yashin AA

Published in: Bull Exp Biol Med 2006; 142 (2): 189-190

Aim of study (acc. to author)

This study was performed to investigate effects of extremely high frequency field on fertility of rats.

Background/further details

10 adult male rats with normal fertility were examined in their spermatogenesis and coupled with unexposed female rats to estimate effects of high frequency field exposure on their offspring (first filial generation, second filial generation, etc.).

Endpoint

effects on the reproductive system: spermatogenesis, effects on the offspring

Exposure

- millimeter waves
- therapeutic/medical device

Exposure	Parameters
Exposure 1: 30–300 GHz Exposure duration: 30 min/day on up to 35 days or 63 days	power density: 0.3 mW/cm² minimum

Exposure 1

Main characteristics

Frequency	30–300 GHz
Type	electric field
Exposure duration	30 min/day on up to 35 days or 63 days
Additional info	A. V. Sergeev, T. I. Subbotina, and A. A. Yashin, Informational Medical Biophysics (Theory, Experiment, and Application) [in Russian], Ed. A. A. Yashin, Tula (2002).

Exposure setup

Exposure source	not specified

Parameters

Measurand	Value	Type	Method	Mass	Remarks
power density	0.3 mW/cm²	minimum	-	-	-

Exposed system:

animal
rat/Wistar
whole body

Methods Endpoint/measurement parameters/methodology

effects on the reproductive system: spermatogenesis (see endpoint: morphol./histopathol. changes), effects on the offspring (e.g. litter size, mutations, fertility)
morphol./histopathol. changes: spermatogenesis (number of normal and abnormal sperm, hematoxylin-eosin stain, light microscopy)

Investigated system:

intact cell/cell culture
isolated organ
sperm, testicle
investigation on living organism

Investigated organ system:

reproductive system

Time of investigation:

after exposure

Main outcome of study (acc. to author)

A remarkable increase in the percentage of abnormal sperm was observed in field exposed rats on days 7, days 21-28 and 35-63 after the start of irradiation. Regarding the offspring, the litter size of first filial generation exceeded normal litter size.

Study character:

medical/biological study
experimental study
full/main study

Study funded by

not stated/no funding

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