To determine if 60 Hz magnetic field can alter the clinical progression of leukemia in rats.
The LGL (large granular lymphocytic) leukemia model was used in this study to induce leukemia in young, male rats within a relatively short period of time by engrafting spleen cells from aged leukemic rats.
A total of 72 animal (divided into 4 groups/18 animals each) were used in this study.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
20 h/day, 7 days/week for up to 10 weeks
|
|
animals were treated in four groups: i) exposure to 1 mT magnetic field ii) no exposure to magnetic field iii) exposure to 0.1 µT magnetic field (ambient control) iv) 5 Gy whole body irradiation from Cobalt-60 4 days before start of exposure to EMF
| Frequency | 60 Hz |
|---|---|
| Type | |
| Waveform | |
| Polarization | |
| Exposure duration | 20 h/day, 7 days/week for up to 10 weeks |
| Exposure source |
|
|---|---|
| Setup | six 10.5 x 3.6 m electrodes, 30 cm apart, arranged vertically, sourrounded by rectangular 1.07 x 4 m coils |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 1 mT | - | measured | - | - |
The clinical progression of LGL leukemia in rats was not significantly altered by a 10 G magnetic field exposure.
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