Study type: Medical/biological study (experimental study)

Immunologic and hematopoietic alterations by 2,450-MHz electromagnetic radiation med./bio.

Published in: Bioelectromagnetics 1980; 1 (1): 77-87

Aim of study (acc. to author)

1) Studies of lymphocytes, and of macrophages in response to different power levels of radiation at 2450 MHz for different durations of exposure in mice, and 2) studies on hematopoietic cells at a power density of 15 mW/cm² are reported.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2,450 MHz
Modulation type: CW
Exposure duration: repeated daily exposure, 30 min/day, for up to 17 days

Exposure 1

Main characteristics
Frequency 2,450 MHz
Type
Charakteristic
Exposure duration repeated daily exposure, 30 min/day, for up to 17 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup The mice were placed unrestrained in individual ventilated polyethylene containers (6 x 6 x 6 cm), four of which were placed in a diamond pattern in the exposure chamber.
Sham exposure A sham exposure was conducted.
Additional info Age-matched control animals were treated simultaneously in the same manner in a sham exposure chamber.
Parameters
Measurand Value Type Method Mass Remarks
power density 15 mW/cm² - - - in most experiments
SAR 11 mW/g - measured - at 15 mW/cm²
power density 5 mW/cm² - - - -
power density 30 mW/cm² - - - -

Reference articles

  • Kinn JB (1977): Whole-body dosimetry of microwave radiation in small animals: The effect of body mass and exposure geometry
  • Elder JA et al. (1975): The effect of microwaves (2450 MHz) on isolated rat liver mitochondria

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A sustained activation of tissue macrophages resulting in suppression of lymphocyte responsiveness and a gradual but temporary stimulation directed to the lymphocytes. Macrophage activation may have caused the early depression of the lymphocyte responsiveness. The study of the other lymphocyte function (i.e. killing of tumor cells) did not show any obvious influence. The radiation affects hematopoietic colony-forming abilities (growth of both erythroid and myeloid cells are altered).

Study character:

Study funded by

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