Study type: Medical/biological study (experimental study)

A study on skin tumour formation in mice with 50 Hz magnetic field exposure med./bio.

Published in: Carcinogenesis 1993; 14 (4): 573-578

Aim of study (acc. to author)

To investigate whether magnetic field exposure is capable to act as a tumor promotor in the DMBA/TPA induced skin tumor model in mice.

Background/further details

An single DMBA dose (25.6 µg) was applied to the skin to initiate tumor development. 8 days thereafter TPA (3.08 µg) was applied twice weekly to promote tumor development, and magnetic field exposure (50 µT or 0.5 mT) was started. Animals were examined after 9, 26, 52 and 103 weeks of magnetic field exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: repeated daily exposure, 21 h/day für 103 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration repeated daily exposure, 21 h/day für 103 weeks
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 50 µT - measured - -
magnetic flux density 500 µT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences in mortality, epidermal thickness (hyperplasia), skin tumor orcurrence, and skin histopathology could be found between the control and the magnetic field exposed groups.

Study character:

Study funded by

Related articles