To study whether simultaneous exposure to a temporally incoherent magnetic field ("noise") could attenuate microwave-induced increases in DNA single-strand breaks and double-strand breaks in brain cells of the rat.
Four treatment groups of rats were investigated: microwave-exposure, noise-exposure (45 mG), microwave + noise-exposure, and sham-exposure.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
2,450 MHz
Modulation type:
CW
Exposure duration:
continuous for 2 h
|
|
|
Exposure 2:
30–100 Hz
Exposure duration:
continuous for 2 h
|
|
Animals were exposed to MW alone, MW plus noise, and noise alone. A sham-exposed animal was included in each run.
| Frequency | 2,450 MHz |
|---|---|
| Type | |
| Charakteristic |
|
| Polarization |
|
| Exposure duration | continuous for 2 h |
| Modulation type | CW |
|---|
| Exposure source |
|
|---|---|
| Setup | Cylindrical waveguides made of galvanized wire screen were excited in TE11 mode [Guy et al., 1979]. Each waveguide contained a plastic chamber to house a rat with enough space to move and a floor made of glass rods. |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 1 mW/cm² | - | - | - | - |
| SAR | 0.6 W/kg | average over mass | cf. remarks | whole body | [Chou et al., 1984] |
| Modulation type | cf. additional info |
|---|---|
| Additional info |
The incoherent magnetic field (ELF noise) was generated using a signal recorded in an audiocassette tape. |
| Exposure source | |
|---|---|
| Setup | For incoherent magnetic field exposure, a waveguide was placed between a pair of Helmholtz coils which were positioned across the plastic cage. E-field shielding was provided by connecting the coil frame made of flexible copper tubing to electrical ground. |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 4.5 µT | mean | measured | - | - |
Data show that brain cells of microwave-exposed rats had significantly higher levels of DNA single-strand breaks and double-strand breaks when compared with sham-exposed animals. Exposure to noise alone did not significantly affect the levels. However, simultaneous noise exposure blocked microwave-induced increases in DNA strand breaks.
These findings indicate that simultaneous exposure to a temporally incoherent magnetic field could block microwave-induced DNA damage in brain cells of the rat.
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