Study type: Medical/biological study (experimental study)

Naltrexone blocks RFR-induced DNA double strand breaks in rat brain cells med./bio.

By: Lai H, Carino M, Singh N
Published in: Wirel Netw 1997; 3 (6): 471-476
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Aim of study (acc. to author)

To study whether endogenous opioids are involved in radiofrequency irradiation-induced DNA double-strand breaks.

Background/further details

Rats were treated with the opioid antagonist naltrexone immediately before and after exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous for 2 h

General information

There were four treatment groups: RFR/naltrexone, sham/naltrexone, RFR/vehicle and sham vehicle.

Exposure 1

Main characteristics
Frequency 2.45 GHz
Charakteristic
  • guided field
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Pulse width 2 µs
Packets per second 500
Exposure setup
Exposure source
  • cylindrical waveguide tubes constructed of galvanized wire screen, TE11 mode
Parameters
Measurand Value Type Method Mass Remarks
power density 20 W/m² mean - - -
SAR 1.2 mW/g mean unspecified whole body -
Additional parameter details

Local SAR in eight brain regions measured in rats exposed in this waveguide system varies from 0.5 W/kg to 2.0 W/kg per mW/cm².

Reference articles

  • Chou CK et al. (1985): Specific absorption rate in rats exposed to 2,450-MHz microwaves under seven exposure conditions
  • Guy AW et al. (1979): Circularly polarized 2450 MHz waveguide system for chronic exposure of small animals to microwaves

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Data showed that the radiofrequency exposure significantly increased DNA double-strand breaks in brain cells of the rat. The effect was partially blocked by treatment with naltrexone. Thus, the results indicate that endogenous opioids play mediating role in radiofrequency exposure-induced DNA double-strand breaks in rat brain cells.

Study character:

Study funded by

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