Study type: Medical/biological study (experimental study)

Effects of GSM-900 microwaves on the experimental allergic encephalomyelitis (EAE) rat model of multiple sclerosis med./bio.

By: Anane R, Geffard M, Taxile M, Bodet D, Billaudel B, Dulou PE, Veyret B
Published in: Bioelectromagnetics 2003; 24 (3): 211-213
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Aim of study (acc. to author)

To investigate the effects of acute exposure to GSM-900 microwaves (900 MHz, 217 Hz pulse modulation) on the clinical parameters of the experimental allergic encephalomyelitis (EAE) model in rats.

Background/further details

EAE is widely used as an animal model for multiple sclerosis (MS) and was induced with a mixture of myelin basic protein and Mycobacterium tuberculosis.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 2 h/day for 21 days
  • SAR: 1.5 W/kg average over mass (brain)
  • SAR: 6 W/kg average over mass (brain)

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration repeated daily exposure, 2 h/day for 21 days
Additional info Reference: Chaillou S. , Leveque P., Luc, J.,, Dale C. , Brishoual M. , Dulou P.E. , Wiart J. 2002 Dosimetric analysis of a loop-antenna for head-exposure of rats and Guinea pig at 900 and 1800 MHz Abstract Book Proc. of 5th International Congress of the European BioElectromagnetic Association EBEA , Helsinki Finland, pp 59-61
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Exposure setup
Exposure source
Setup Rats were restrained in Plexiglas restrainers with a loop antenna placed over their heads. The loop antenna exposure system (see reference article) consisted of two parallel lines on a printed circuit board, ending in a rectangular loop (3 x 1 cm). The antenna was fed in the middle, thus acting as a resonator tuned by means of a sliding shorting element, using a network analyzer. The setup was powered by a 10 W GSM generator, coupled to a 50 dB broadband amplifier.
Additional info In each of the two independent experiments, the rats were divided into four groups: exposed to 1.5 or 6.0 W/kg local SAR, sham exposed and cage control.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.5 W/kg average over mass measured and calculated brain -
SAR 6 W/kg average over mass measured and calculated brain -
Measurement and calculation details

The local SAR was measured in solid homogeneous gel phantoms and calculated using the FDTD method on homogeneous and multitissue phantoms. The SAR levels used in these experiments were calculated over the whole brain in a numerical multitissue phantom. These calculations were calibrated in a homogeneous phantom using thermistor and electric field probes to measure the local SAR.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

There was no effect of a 21 day exposure (2h/day) on the onset, duration, and termination of the EAE-crisis.

Study character:

Study funded by

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