Study type: Medical/biological study (experimental study)

Anti-pressor effects of whole body exposure to static magnetic field on pharmacologically induced hypertension in conscious rabbits med./bio.

By: Okano H, Ohkubo C
Published in: Bioelectromagnetics 2003; 24 (2): 139-147
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Aim of study (acc. to author)

To investigate the effects of static magnetic field exposure on pharmacologically induced hypertension in rabbits.

Background/further details

Hypertensive and vasoconstrictive actions were induced by L-NAME (a nonselective NOS inhibitor) or norepinephrine.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: 30 min

Exposure 1

Main characteristics
Frequency
Type
Exposure duration 30 min
Exposure setup
Exposure source
Setup rabbit was placed in a holder which was set into the annular electromagnet.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 50 µT unspecified estimated - geomagnetic field at the laboratory
magnetic flux density 500 µT peak value measured - to 4.0 mT; in the head
magnetic flux density 1 mT peak value measured - to 4.0 mT; in the throat
magnetic flux density 1 mT maximum measured - in the ear lobe
magnetic flux density 5 mT peak value measured - to 5.5 mT; in the trunk
Additional parameter details

The estimated values of max gradients were approximately 0.01 mT/mm in the trunk, 0.06 mT/mm in the head, 0.09 mT/mm in the throat and 0.04 mT/mm in the ear lobe.

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Without treatment of pharmacological agents, no statistically significant differences in the hemodynamics and blood pressure changes were observed between sham and static magnetic field (SMF) exposure.
Under pharmacologically induced hypertensive conditions, SMF exposure leads to significantly attenuated vasoconstriction and suppressed elevation of blood pressure.
No statistically significant changes in the vasoactive substances were found.

Study character:

Study funded by

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