To investigate the effects of MRI exposure on the permeability of blood-brain barriere to a radioactive tracer substance in rats.
In this study radioactive labelled diethylenetriaminepentaacetic acid (Gadolinum-DTPA) was used as tracer substance.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
Exposure duration:
2 x 23.2 min
|
|
|
Exposure 2:
6.25 MHz
Modulation type:
pulsed
Exposure duration:
2x 23,2 min
|
|
|
Exposure 3:
10–200 Hz
Modulation type:
pulsed
Exposure duration:
2x 23,2 min
|
|
Aminals were exposed to multislice transverse 30 ms spin echo sequence.
| Frequency | |
|---|---|
| Type | |
| Exposure duration | 2 x 23.2 min |
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 0.32 m |
| Setup | Rats were anaesthetized with 50 mg/kg sodium pentobarbital prior to the exposure. Immediately after the exposure rats were injected with 25 µCi of [153Gd]DTPA and then were immediately exposed again. During the sham exposure, all magnetic and RF fields were off but sound and vibration exposure was simulated through an audio playback of the noise produced by the imaging sequence. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 150 mT | maximum | - | - | - |
| Frequency | 10–200 Hz |
|---|---|
| Type | |
| Exposure duration | 2x 23,2 min |
| Additional info | 3 gradient fields in x-, y-, z-direction |
| Exposure source |
|
|---|---|
| Distance between exposed object and exposure source | 0.32 m |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 400 mT | maximum | - | - | in x- and y-direction |
| magnetic flux density | 150 mT | maximum | - | - | in z-direction |
The findings of this study suggest that magnetic fields like the applicated MRI exposure may alter the permeability of the blood-brain barrier of rats.
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