Study type: Therapeutical study (experimental study)

Effect of low grade radiofrequency heating on arterial vasospasm in the porcine model med./bio.

By: Mitchel JF, McKay RG, Azrin MA, Aretz TA, Waters DD, Fram DB
Published in: Cathet Cardiovasc Diagn 1997; 42 (3): 348-355
Download citation in RIS format

Aim of study (acc. to author)

To assess the effect of low grade, radiofrequency-powered, thermal balloon angioplasty on the vasoconstrictor response of peripheral arteries.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 640 kHz
Modulation type: CW
Exposure duration: 90 s

Exposure 1

Main characteristics
Frequency 640 kHz
Type
Exposure duration 90 s
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup electrodes inside a balloon dilatation catheter
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 100 W - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The study has demonstrated that low grade radiofrequency heating to 60°C during thermal balloon angioplasty results in significant attenuation of mechanically induced vasospasm in peripheral porcine arteries. This effect is probably due to thermal necrosis of myocytes and the degree of vasomotor attenuation is likely to be directly related to the extent of myocyte necrosis.

Study character:

Study funded by