Examination of effect of continuous-wave or pulsed wave microwave energy on the cerebrovascular permeability area product for [14C]sucrose at the blood-brain barrier of rats.
The cerebrovascular permeability area product is the product of cerebrovascular permeability and capillary surface area per cubic centimeter of brain.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
2.8 GHz
Modulation type:
CW
Exposure duration:
continuous for 30 min
|
|
|
Exposure 2:
2.8 GHz
Modulation type:
pulsed
Exposure duration:
continuous for 30 min
|
|
| Frequency | 2.8 GHz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | continuous for 30 min |
| Modulation type | CW |
|---|
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 0.68 m |
| Chamber | anechoic chamber (512 ft³) maintained at 27°C. |
| Setup | rats were placed in a styrofoam form-fitting holder located 68 cm from the horn |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 10 mW/cm² | unspecified | - | - | - |
| power density | 40 mW/cm² | unspecified | - | - | - |
| Frequency | 2.8 GHz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | continuous for 30 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 2 µs |
| Repetition frequency | 500 Hz |
| Exposure source |
|
|---|---|
| Distance between exposed object and exposure source | 0.68 m |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 1 mW/cm² | unspecified | - | - | - |
| power density | 5 mW/cm² | unspecified | - | - | - |
| power density | 10 mW/cm² | unspecified | - | - | - |
| power density | 15 mW/cm² | unspecified | - | - | - |
Regardless of the power density level of the microwaves, the permeability area product for [14C]sucrose in any brain region was not significantly different from that in the sham-irradiated control animals. The findings indicate that microwave irradiation under the given experimental conditions does not damage the blood-brain barrier.
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